Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat
Source of Publication
Journal of Diabetes Research
© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.
Al Kury, L.; Smail, M.; Qureshi, M. A.; Sydorenko, V.; Shmygol, A.; Oz, M.; Singh, J.; and Howarth, F. C., "Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat" (2018). Scopus Indexed Articles. 1220.