Title

An updated mini review of Vitamin D and obesity: Adipogenesis and inflammation state

Source of Publication

Macedonian Journal of Medical Sciences

Abstract

© 2016 Zujaja-Tul-Noor Hamid Mehmood, Dimitrios Papandreou. Vitamin D related research continues to expand and theorise regarding its involvement in obesity, as both hypovitaminosis D and obesity strike in pandemic proportions. Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Due to this characteristic, it is potentially linked to obesity, which is a state of inflammation involving the release of cytokines from adipose tissue, and exerting stress on other organs in a state of positive energy balance. Research trials in the past couple of years and systematic reviews from SCOPUS and MEDLINE will be discussed. The role of Vitamin D throughout the lifespan (from fetal imprinting until older age), and in various other obesity mediated chronic conditions shall be highlighted. Various mechanisms attributed to the inverse relationship of Vitamin D and obesity are discussed with research gaps identified, particularly the role of adipokines, epigenetics, calcium and type of adipose tissue.

Document Type

Article

First Page

526

Last Page

532

Publication Date

9-15-2016

DOI

10.3889/oamjms.2016.103

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