Title

Carbapenem-Resistant, Gram-Negative Bacilli: The State of the Art. The State of the Art

Source of Publication

Antibiotic Resistance: Mechanisms and New Antimicrobial Approaches

Abstract

© 2016 Elsevier Inc. All rights reserved. The evolution of antimicrobial resistance in bacteria is a complex and longstanding process that has gathered much attention by outpacing the discovery and development of new antibiotics. Among Gram-negative bacilli, resistance has been progressive and unremitting in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii. In particular, the spread of carbapenem-resistant, Gram-negative bacilli during the last decade has escalated worldwide, resulting in severe infections, some of which respond to only a few therapeutic options. Often viewed as last-resort antibiotics, carbapenems are rendered inactive against bacteria via the production of carbapenem-hydrolyzing enzymes, utilization of impermeable cell wall porins, active expulsion of carbapenem molecules by efflux pumps, production of mutant penicillin-binding proteins, or a combination. This chapter describes the mechanisms and epidemiology of resistance to carbapenems in Gram-negative pathogens. It also sheds a light on laboratory detection of these pathogens and presents available control and therapeutic options for their containment.

Document Type

Article

ISBN

9780128036686,9780128036426

Publisher

Elsevier

First Page

93

Last Page

119

Publication Date

6-24-2016

DOI

10.1016/b978-0-12-803642-6.00005-8

Scopus ID

84987912476

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