Source of Publication
© 2018 by the authors Chemotherapy-induced nausea and vomiting (CINV) remain the most common and devastating side-effects associated with cancer chemotherapy. In recent decades, several lines of research emphasize the importance of 5-hydroxytryptamine3 (5-HT3; serotonin) receptors in the pathogenesis and treatment of CINV. 5-HT3 receptors are members of ligand-gated ion channels that mediate the rapid and transient membrane-depolarizing effect of 5-HT in the central and peripheral nervous system. These receptors play important roles in nausea and vomiting, as well as regulation of peristalsis and pain transmission. The development of antagonists for 5-HT3 receptor dramatically improved the treatment of CINV in cancer patients. In fact, the most common use of 5-HT3 receptor antagonists to date is the treatment of nausea and vomiting. In recent years, there has been an increasing tendency to use natural plant products as important therapeutic entities in the treatment of various diseases. In this article, we examined the results of earlier studies on the actions of natural compounds on the functional properties of 5-HT3 receptors. It is likely that these natural modulators of 5-HT3 receptors can be employed as lead structures for the synthesis of therapeutic agents for treating CINV in future clinical studies.
Medicine and Health Sciences
5-hydroxytryptamine3 receptor antagonists, 5-hydroxytryptamine3 receptors, Chemotherapy-induced nausea and vomiting, Negative allosteric modulators
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This work is licensed under a Creative Commons Attribution 4.0 License.
Al Kury, Lina T.; Mahgoub, Mohamed; Howarth, Frank Christopher; and Oz, Murat, "Natural negative allosteric modulators of 5-HT3 receptors" (2018). All Works. 2474.
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Open Access Type
Gold: This publication is openly available in an open access journal/series