Document Type
Article
Source of Publication
Molecules
Publication Date
9-1-2020
Abstract
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Resveratrol (3,40,5 trihydroxystilbene) is a naturally occurring non-flavonoid polyphenol. It has various pharmacological effects including antioxidant, anti-diabetic, anti-inflammatory and anti-cancer. Many studies have given special attention to different aspects of resveratrol anti-cancer properties and proved its high efficiency in targeting multiple cancer hallmarks. Tumor microenvironment has a critical role in cancer development and progression. Tumor cells coordinate with a cast of normal cells to aid the malignant behavior of cancer. Many cancer supporting players were detected in tumor microenvironment. These players include blood and lymphatic vessels, infiltrating immune cells, stromal fibroblasts and the extracellular matrix. Targeting tumor microenvironment components is a promising strategy in cancer therapy. Resveratrol with its diverse biological activities has the capacity to target tumor microenvironment by manipulating the function of many components surrounding cancer cells. This review summarizes the targets of resveratrol in tumor microenvironment and the mechanisms involved in this targeting. Studies discussed in this review will participate in building a solid ground for researchers to have more insight into the mechanism of action of resveratrol in tumor microenvironment.
DOI Link
ISSN
Publisher
MDPI AG
Volume
25
Issue
18
First Page
4282
Disciplines
Computer Sciences | Medicine and Health Sciences
Keywords
Anti-cancer, Natural products, Phytotherapy, Resveratrol, Tumor microenvironment
Scopus ID
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Talib, Wamidh H.; Alsayed, Ahmad Riyad; Farhan, Faten; and Al Kury, Lina T., "Resveratrol and tumor microenvironment: mechanistic basis and therapeutic targets" (2020). All Works. 2957.
https://zuscholars.zu.ac.ae/works/2957
Indexed in Scopus
yes
Open Access
yes
Open Access Type
Gold: This publication is openly available in an open access journal/series