Source of Publication
Journal of cancer prevention
Nitric oxide (NO) in general plays a beneficial physiological role as a vasorelaxant and the role of NO is decided by its concentration present in physiological environments. NO either facilitates cancer-promoting characters or act as an anti-cancer agent. The dilemma in this regard still remains unanswered. This review summarizes the recent information on NO and its role in carcinogenesis and tumor progression, as well as dietary chemopreventive agents which have NO-modulating properties with safe cytotoxic profile. Understanding the molecular mechanisms and cross-talk modulating NO effect by these chemopreventive agents can allow us to develop better therapeutic strategies for cancer treatment.
Korean Society of Cancer Prevention
Medicine and Health Sciences
Chemoprevention; Endothelial nitric oxide synthase; Inducible nitric oxide synthase; Neoplasms; Nitric oxide
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial 4.0 License
Vahora, Huzefa; Khan, Munawwar Ali; Alalami, Usama; and Hussain, Arif, "The Potential Role of Nitric Oxide in Halting Cancer Progression Through Chemoprevention" (2016). All Works. 3538.
Indexed in Scopus
Open Access Type
Gold: This publication is openly available in an open access journal/series