Title

An application of ionic liquid for preparation of homogeneous collagen and alginate hydrogels for skin dressing

Document Type

Article

Source of Publication

Journal of Molecular Liquids

Publication Date

10-1-2017

Abstract

© 2017 Ionic liquid due to its green nature as well as having the ability to dissolve biopolymer, was used in the preparation of collagen and alginate hydrogels. The collagen and alginate hydrogels were prepared in different ratios of collagen and alginate, labeled CA5040, CA6030 and CA7020. The prepared hydrogels were characterized with Fourier-transform infrared spectroscopy (FTIR), Scanning electron microscope (SEM), Thermogravimetric analysis (TGA) analysis. The samples were evaluated for water uptake behavior and mechanical properties using electrodynamic fatigue testing system. The biocompatibility was assessed through hemolysis and MTT assay on rat mesenchymal stem cells (rMSC) which showed satisfactory results. The drug loading and subsequent antibacterial properties were also performed. The prepared collagen and alginate hydrogels are suggested to be used for skin dressing.

ISSN

0167-7322

Publisher

Elsevier B.V.

Volume

243

First Page

720

Last Page

725

Disciplines

Life Sciences

Keywords

Biocompatibility, Collagen, Hydrogels, Ionic liquid, Skin dressing

Scopus ID

85028558505

Indexed in Scopus

yes

Open Access

no

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