A Deep Learning-Based Approach For Automatic Segmentation And Quantification Of The Left Ventricle From Cardiac Cine Mr Images

Hisham Abdeltawab, University of Louisville
Fahmi Khalifa, University of Louisville
Fatma Taher, Zayed University
Norah Saleh Alghamdi, Princess Nourah Bint Abdulrahman University
Mohammed Ghazal, University of Louisville
Garth Beache, University of Louisville
Tamer Mohamed, University of Louisville
Robert Keynton, University of Louisville
Ayman El-Baz, University of Louisville


Cardiac MRI has been widely used for noninvasive assessment of cardiac anatomy and function as well as heart diagnosis. The estimation of physiological heart parameters for heart diagnosis essentially require accurate segmentation of the Left ventricle (LV) from cardiac MRI. Therefore, we propose a novel deep learning approach for the automated segmentation and quantification of the LV from cardiac cine MR images. We aim to achieve lower errors for the estimated heart parameters compared to the previous studies by proposing a novel deep learning segmentation method. Our framework starts by an accurate localization of the LV blood pool center-point using a fully convolutional neural network (FCN) architecture called FCN1. Then, a region of interest (ROI) that contains the LV is extracted from all heart sections. The extracted ROIs are used for the segmentation of LV cavity and myocardium via a novel FCN architecture called FCN2. The FCN2 network has several bottleneck layers and uses less memory footprint than conventional architectures such as U-net. Furthermore, a new loss function called radial loss that minimizes the distance between the predicted and true contours of the LV is introduced into our model. Following myocardial segmentation, functional and mass parameters of the LV are estimated. Automated Cardiac Diagnosis Challenge (ACDC-2017) dataset was used to validate our framework, which gave better segmentation, accurate estimation of cardiac parameters, and produced less error compared to other methods applied on the same dataset. Furthermore, we showed that our segmentation approach generalizes well across different datasets by testing its performance on a locally acquired dataset. To sum up, we propose a deep learning approach that can be translated into a clinical tool for heart diagnosis. (C) 2020 Elsevier Ltd. All rights reserved.