Document Type
Article
Source of Publication
Materials Technology
Publication Date
3-21-2025
Abstract
Oral pathogen biofilms contribute to chronic infections, while oral cancer remains a significant health threat, emphasizing the need for effective therapeutic strategies. This study investigates the fabrication, characterization, and therapeutic potential of copper oxide-stigmasterol nanoparticles (CuO-SS NPs) for oral pathogen biofilm disruption and oral cancer treatment. The antimicrobial activity of CuO-SS NPs was evaluated against oral pathogens, including S. aureus, S. mutans, E. faecalis, and C. albicans. In cancer cell studies, CuO-SS NPs exhibited a concentration-dependent cytotoxicity, reducing cell viability from 88% at 15 µg/mL to 29.33% at 120 µg/mL, comparable to doxorubicin (24.3%). The CuO-SS NPs significantly upregulated the apoptosis markers (Caspase-3, Caspase-8, and FasL) by 4.05, 1.4, and 3.1 fold, respectively. These results highlight the potential of CuO-SS NPs as a dual-purpose therapeutic for oral infections and cancer.
DOI Link
ISSN
Publisher
Informa UK Limited
Volume
40
Issue
1
First Page
2476999
Last Page
2476999
Disciplines
Engineering
Keywords
Copper oxide nanoparticles, Stigmasterol, Oral pathogens, Biofilm disruption, Oral cancer
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Hussain, Althaf; Ghimouz, Rym; Panda, Siva Prasad; Panigrahy, Uttam Prasad; Marunganathan, Vanitha; Shaik, Mohammed Rafi; Deepak, Paramasivam; Thiyagarajulu, Nathiya; Shaik, Baji; Antonyraj, Anahas Perianaika Matharasi; Shah, Mohd Asif; and Guru, Ajay, "Synergistic effects of copper oxide-stigmasterol nanoparticles: a novel therapeutic strategy for oral pathogen biofilms and oral cancer" (2025). All Works. 7175.
https://zuscholars.zu.ac.ae/works/7175
Indexed in Scopus
no
Open Access
yes
Open Access Type
Hybrid: This publication is openly available in a subscription-based journal/series