Document Type
Article
Source of Publication
Frontiers in Immunology
Publication Date
5-25-2025
Abstract
Chemotherapeutic resistance is a major obstacle to chemotherapeutic failure. Cancer cell resistance involves several mechanisms, including epithelial-to-mesenchymal transition (EMT), signaling pathway bypass, drug efflux activation, and impairment of drug entry. P-glycoproteins (P-gp) are an efflux transporter that pumps chemotherapeutic drugs out of cancer cells, resulting in chemotherapeutic resistance. Several types of long noncoding RNA (lncRNAs) have been identified in resistant cancer cells, including ODRUL, MALAT1, and ANRIL. The high expression level of ODRUL is related to the induction of ATP-binding cassette (ABC) gene expression, resulting in the emergence of doxorubicin resistance in osteosarcoma. lncRNAs are observed to be regulators of drug transporters in cancer cells such as MALAT1 and ANRIL. Targeting P-gp expression using natural products is a new strategy to overcome cancer cell resistance and improve the sensitivity of resistant cells toward chemotherapies. This review validates the inhibitory effects of natural products on P-gp expression and activity using in silico molecular docking. In silico analysis showed that Delphinidin and Asparagoside-f are the most significant natural product inhibitors of p-glycoprotein-1. These inhibitors can reverse multi-drug resistance and induce the sensitivity of resistant cancer cells toward chemotherapy based on in silico molecular docking. It is important to validate that pre-elementary docking can be confirmed using in vitro and in vivo experimental data.
DOI Link
ISSN
Volume
16
Disciplines
Computer Sciences | Medicine and Health Sciences
Keywords
chemoresistance, efflux transporters, in silico analysis, lncRNA, p-glycoprotein-1
Scopus ID
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Diab, Mohanad; Hamdi, Amel; Al-Obeidat, Feras; Hafez, Wael; Cherrez-Ojeda, Ivan; Gador, Muneir; Rashid, Gowhar; Elkhazin, Sana F.; Ibrahim, Mahmad Anwar; Ismail, Tarek Farag; and Alkafaas, Samar Sami, "Discovery of drug transporter inhibitors tied to long noncoding RNA in resistant cancer cells; a computational model -in silico- study" (2025). All Works. 7298.
https://zuscholars.zu.ac.ae/works/7298
Indexed in Scopus
yes
Open Access
yes
Open Access Type
Gold: This publication is openly available in an open access journal/series