Source of Publication
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Background: Malnutrition can significantly affect disease progression and patient survival. The efficiency of weight loss and bioimpedance analysis (BIA)-derived measures in the evaluation of malnutrition, and disease progression and prognosis in patients with head and neck cancer (HNC) are an important area of research. Method: The PubMed database was thoroughly searched, using relative keywords in order to identify clinical trials that investigated the role of BIA-derived measures and weight loss on the disease progression and prognosis of patients with HNC. Twenty-seven studies met the criteria. More specifically, six studies examined the prognostic role of the tissue electrical properties in HNC patients; five examined the role of the tissue electrical properties on identifying malnutrition; four studies looked at the changes in the tissue electrical properties of HNC patients; and 12 examined the prognostic role of weight loss on survival and/or treatment outcomes. Results: Several studies have investigated the role of nutritional status tools on prognosis in HNC patients. Current studies investigating the potential of BIA-derived raw data have shown that phase angle (PA) and capacitance of the cell membrane may be considered prognostic factors of survival. Weight loss may be a prognostic factor for treatment toxicity and survival, despite some conflicting evidence. Conclusions: Further studies are recommended to clarify the role of BIA-derived measures on patients’ nutritional status and the impact of PA on clinical outcomes as well as the prognostic role of weight loss.
Bioelectrical impedance analysis, Body mass index, Head and neck cancer, Prognostic factor, Weight loss
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Mantzorou, Maria; Tolia, Maria; Poultsidi, Antigoni; Pavlidou, Eleni; Papadopoulou, Sousana K.; Papandreou, Dimitrios; and Giaginis, Constantinos, "Can bioelectrical impedance analysis and BMI be a prognostic tool in head and neck cancer patients? A review of the evidence" (2020). All Works. 817.
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Gold: This publication is openly available in an open access journal/series