ORCID Identifiers

0000-0002-4078-2049

Document Type

Article

Source of Publication

Clinical and Experimental Dental Research

Publication Date

1-1-2017

Abstract

©2017 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. The microbial profile of aggressive periodontitis patients is considered to be complex with variations among populations in different geographical areas. The aim of this study was to assess the presences of 4 putative periodontopathic bacteria (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola) and 2 periodontal herpes viruses (Epstein–Barr virus type 1 [EBV-1] and human cytomegalovirus [HMCV]) in subgingival plaque of Sudanese subjects with aggressive periodontitis and healthy controls. The study group consisted of 34 subjects, 17 aggressive periodontitis patients and 17 periodontally healthy controls (14–19 years of age). Pooled subgingival plaque samples were collected and analyzed for detection of bacteria and viruses using loop-mediated isothermal amplification. Prevalence of subgingival A. actinomycetemcomitans, HCMV, and P. gingivalis were significantly higher among aggressive periodontitis patients than periodontally healthy controls. Coinfection with A. actinomycetemcomitans, HCMV, and/or EBV-1 was restricted to the cases. Increased risk of aggressive periodontitis was the highest when A. actinomycetemcomitans was detected together with EBV-1 (OD 49.0, 95% CI [2.5, 948.7], p =.01) and HCMV (OD 39.1, 95% CI [2.0, 754.6], p =.02). In Sudanese patients, A. actinomycetemcomitans and HCMV were the most associated test pathogens with aggressive periodontitis.

ISSN

2057-4347

Publisher

Wiley-Blackwell

Volume

3

Issue

5

First Page

183

Last Page

190

Disciplines

Life Sciences

Keywords

aggressive periodontitis, cytomegalovirus, Epstein–Barr virus, loop-mediated isothermal amplification (LAMP), periodontal microbiota, subgingival plaque

Scopus ID

85038001477

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

Included in

Life Sciences Commons

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