Source of Publication
© 2019 The Author(s). Purpose: Tumor necrosis factor-α (TNF-α), secreted by the activated macrophages, may participate in the onset and progression of colorectal cancer (CRC). The association of TNF-α –308 G>A (rs1800629) single-nucleotide polymorphism (SNP) with CRC risk has been investigated by many studies but the results are inconclusive. A trial sequential meta-analysis was performed for precise estimation of the relationship between TNF-α –308 G>A gene polymorphism with CRC risk. Methods: Medline (PubMed), EMBASE (Excerpta-Medica) and Google Scholar were mined for relevant articles. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to estimate the significance of association. Results: The pooled analysis indicated no risk associated with TNF-α –308 G>A SNP and overall CRC risk in five genetic comparison models, i.e. allelic (A vs. G: P = 0.524; OR = 1.074, 95% CI = 0.863–1.335), homozygous (AA vs. GG: P = 0.489; OR = 1.227, 95% CI = 0.688–2.188), heterozygous (AG vs. GG: P = 0.811; OR = 1.024, 95% CI = 0.843–1.244), dominant (AA+AG vs. GG: P = 0.630; OR = 1.055, 95% CI = 0.849–1.311) and recessive (AA vs. AG+GG: P = 0.549; OR = 1.181, 95% CI = 0.686–2.033). Subgroup analysis revealed that TNF-α –308 G>A SNP is associated with reduced risk of CRC in Asian ethnicity. The study showed no publication bias. Conclusions: No association of TNF-α –308 G>A SNP with overall CRC risk was found. This SNP is likely to be protective against CRC in Asian population when compared with Caucasian population. Larger prospective-epidemiological studies are warranted to elucidate the roles of TNF-α –308 G>A SNP in the etiology of CRC and to endorse the present findings.
Portland Press Ltd
tumor necrosis factor, Article, Asian, cancer risk, cancer susceptibility, Caucasian, colorectal cancer, gene frequency, genetic association, genetic variability, genotype, heterozygosity, homozygosity, human, population risk, risk factor, risk reduction, single nucleotide polymorphism, TNF alpha gene
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Mandal, Raju K.; Khan, Munawwar Ali; Hussain, Arif; Akhter, Naseem; Jawed, Arshad; Dar, Sajad A.; Wahid, Mohd; Panda, Aditya K.; Lohani, Mohtashim; Mishra, Bhartendu N.; and Haque, Shafiul, "A trial sequential meta-analysis of TNF-α –308G>A (rs800629) gene polymorphism and susceptibility to colorectal cancer" (2019). All Works. 305.
Indexed in Scopus
Open Access Type
Gold: This publication is openly available in an open access journal/series