Source of Publication
Molecules (Basel, Switzerland)
Cancer is considered the second leading cause of death worldwide and in 2018 it was responsible for approximately 9.6 million deaths. Globally, about one in six deaths are caused by cancer. A strong correlation was found between diabetes mellitus and carcinogenesis with the most evident correlation was with type 2 diabetes mellitus (T2DM). Research has proven that elevated blood glucose levels take part in cell proliferation and cancer cell progression. However, limited studies were conducted to evaluate the efficiency of conventional therapies in diabetic cancer patients. In this review, the correlation between cancer and diabetes will be discussed and the mechanisms by which the two diseases interact with each other, as well as the therapeutics challenges in treating patients with diabetes and cancer with possible solutions to overcome these challenges. Natural products targeting both diseases were discussed with detailed mechanisms of action. This review will provide a solid base for researchers and physicians to test natural products as adjuvant alternative therapies to treat cancer in diabetic patients.
Medicine and Health Sciences
alternative therapies, cancer, cancer metabolism, hyperglycemia, hyperinsulinemia, metabolic syndrome, natural products, obesity, oxidative stress, Warburg effect
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Talib, Wamidh H.; Mahmod, Asma Ismail; Abuarab, Sara Feras; Hasen, Eliza; Munaim, Amer A.; Haif, Shatha Khaled; Ayyash, Amani Marwan; Khater, Samar; Al-Yasari, Intisar Hadi; and Al Kury, Lina T., "Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products" (2021). All Works. 4195.
Indexed in Scopus
Open Access Type
Gold: This publication is openly available in an open access journal/series