Title

Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines

Document Type

Article

Source of Publication

Molecular Diversity

Publication Date

1-1-2021

Abstract

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract: [Figure not available: see fulltext.]

ISSN

1381-1991

Disciplines

Engineering

Keywords

Amide, Antioxidant, Oxadiazole, Synthesis

Scopus ID

85110946625

Indexed in Scopus

yes

Open Access

no

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