Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines

Author First name, Last name, Institution

Merla Arjuna Rajendra, SSIT
Muhammad Naseem, Zayed University
Muthipeedika Nibin Joy, Ural Federal University
K. Sunil, SSIT
Ayyiliath Meleveetil Sajith, Kannur University
Fares Howari, Zayed University
Yousef Nazzal, Zayed UniversityFollow
Cijo Xavier, Zayed University
Mohammed B. Alshammari, Prince Sattam Bin Abdulaziz University
Karickal Raman Haridas, Kannur University

Document Type

Article

Source of Publication

Molecular Diversity

Publication Date

1-1-2021

Abstract

We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract: [Figure not available: see fulltext.]

DOI Link

10.1007/s11030-021-10275-7

ISSN

1381-1991

Disciplines

Engineering

Keywords

Amide, Antioxidant, Oxadiazole, Synthesis

Scopus ID

85110946625

Recommended Citation

Rajendra, Merla Arjuna; Naseem, Muhammad; Joy, Muthipeedika Nibin; Sunil, K.; Sajith, Ayyiliath Meleveetil; Howari, Fares; Nazzal, Yousef; Xavier, Cijo; Alshammari, Mohammed B.; and Haridas, Karickal Raman, "Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines" (2021). All Works. 4411.
https://zuscholars.zu.ac.ae/works/4411

Indexed in Scopus

yes

Open Access

no