Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines
Source of Publication
We herein report a modified methodology for the synthesis of some oxadiazoles linked to amides under mild conditions. The developed protocol using NMI-TfCl has been found to be effective and tolerant for the amide bond formation reaction of a series of electronically deactivating and sterically challenging amines. The antioxidant potential of the newly synthesized compounds has been evaluated at the later stage. Graphic abstract: [Figure not available: see fulltext.]
Amide, Antioxidant, Oxadiazole, Synthesis
Rajendra, Merla Arjuna; Naseem, Muhammad; Joy, Muthipeedika Nibin; Sunil, K.; Sajith, Ayyiliath Meleveetil; Howari, Fares; Nazzal, Yousef; Xavier, Cijo; Alshammari, Mohammed B.; and Haridas, Karickal Raman, "Application of NMI-TfCl-mediated amide bond formation in the synthesis of biologically relevant oxadiazole derivatives employing less basic (hetero)aryl amines" (2021). All Works. 4411.
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