Source of Publication
Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 (n = 453; 70.12%) and a critical group (n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
Medicine and Health Sciences
COVID-19, Genotypes, Metabolism, Polymorphism, UAE, Vitamin D
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This work is licensed under a Creative Commons Attribution 4.0 International License.
Al-Anouti, Fatme; Mousa, Mira; Karras, Spyridon N.; Grant, William B.; Alhalwachi, Zainab; Abdel-Wareth, Laila; Uddin, Maimunah; Alkaabi, Nawal; Tay, Guan K.; Mahboub, Bassam; and Alsafar, Habiba, "Associations between genetic variants in the vitamin d metabolism pathway and severity of covid-19 among uae residents" (2021). All Works. 4623.
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Gold: This publication is openly available in an open access journal/series