Source of Publication
Peptide hormones play a crucial role in body weight and glucose homeostasis. In this study, we aimed to explore this association and recruited 43 obese and 31 age-and sex-matched lean participants. We assessed their body mass index (BMI), waist circumference (WC), waist-to-height ratio (WtHR), percentage body fat (PBF), fasting blood levels of peptide hormones (GLP-1, GLP-2, insulin, leptin, ghrelin, CCK, and PYY), fasting blood sugar (FBS), and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR). We tested the associations between peptide hormones and markers of obesity and insulin resistance (IR) by using the Independent-Samples t-test and Mann-Whitney U test, partial correlation, and logistic regression. FBS, insulin, HOMA-IR, GLP-1, GLP-2, and leptin were significantly higher in the obese group; ghrelin and CCK were significantly higher in lean participants, and no difference was seen for PYY. Controlling for BMI, GLP-1 was positively correlated with WtHR, while ghrelin was inversely correlated with WtHR. GLP-1 was correlated with HOMA-IR. GLP-1 was associated with obesity and IR markers in the regression model. Our results show that obese and lean adults display significant differences in plasma peptide hormone levels. GLP-1 levels were independently associated with markers of obesity and IR. Restoring the appetite hormone balance in obesity may represent a potential therapeutic target.
Medicine and Health Sciences
Brain–gut axis, Cholecystokinin, Ghrelin, Glucagon-like peptide-1, Glucagon-like peptide-2, Insulin, Insulin resistance, Leptin, Obesity, Peptide yy
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ali Ahmad, Manal; Karavetian, Mirey; Moubareck, Carole Ayoub; Wazz, Gabi; Mahdy, Tarek; and Venema, Koen, "The Association between Peptide Hormones with Obesity and Insulin Resistance Markers in Lean and Obese Individuals in the United Arab Emirates" (2022). All Works. 4957.
Indexed in Scopus
Open Access Type
Gold: This publication is openly available in an open access journal/series