Source of Publication
Frontiers in Aging Neuroscience
The intricate interplay of one-carbon metabolism (OCM) with various cellular processes has garnered substantial attention due to its fundamental implications in several biological processes. OCM serves as a pivotal hub for methyl group donation in vital biochemical reactions, influencing DNA methylation, protein synthesis, and redox balance. In the context of aging, OCM dysregulation can contribute to epigenetic modifications and aberrant redox states, accentuating cellular senescence and age-associated pathologies. Furthermore, OCM's intricate involvement in cancer progression is evident through its capacity to provide essential one-carbon units crucial for nucleotide synthesis and DNA methylation, thereby fueling uncontrolled cell proliferation and tumor development. In neurodegenerative disorders like Alzheimer's and Parkinson's, perturbations in OCM pathways are implicated in the dysregulation of neurotransmitter synthesis and mitochondrial dysfunction, contributing to disease pathophysiology. This review underscores the profound impact of OCM in diverse disease contexts, reinforcing the need for a comprehensive understanding of its molecular complexities to pave the way for targeted therapeutic interventions across inflammation, aging and neurodegenerative disorders.
Frontiers Media SA
Medicine and Health Sciences
One-carbon metabolism, Aging, Neurodegenerative diseases, Epigenetic modifications, Cellular senescence
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Ghanem, Ayman Bou; Hussayni, Yaman; Kadbey, Raghid; Ratel, Yara; Yehya, Shereen; Khouzami, Lara; Ghadieh, Hilda E.; Kanaan, Amjad; Azar, Sami; and Harb, Frederic, "Exploring the complexities of 1C metabolism: implications in aging and neurodegenerative diseases" (2024). All Works. 6344.
Indexed in Scopus
Open Access Type
Gold: This publication is openly available in an open access journal/series