Frequency of rs731236 (Taql), rs2228570 (Fok1) of Vitamin-D Receptor (VDR) gene in Emirati healthy population

Author First name, Last name, Institution

Enas Osman, Khalifa University of Science and Technology
Fatme Al Anouti, Zayed UniversityFollow
Gehad El ghazali, Institute of Medicine
Afrozul Haq, VPS Healthcare
Rajaa Mirgani, Fatima College of Health Sciences
Habiba Al Safar, Khalifa University of Science and Technology

ORCID Identifiers

0000-0001-7141-1438

Document Type

Article

Source of Publication

Meta Gene

Publication Date

12-1-2015

Abstract

© 2015 The Authors. Published by Elsevier B.V.. Vitamin D is getting more attention everyday due to its importance in maintaining bone and calcium homeostasis, cellular proliferation, differentiation and immune response. Vitamin D is derived from diet or elicited in the skin by the activation of 7-dehydrocholesterol, which is an inert molecule that must be activated by ultraviolet light to form pre-vitamin D3. Recent studies connected the gene encoding for vitamin D (VDR) to the genetic control of bone mass and other diseases. As VDR SNPs have been associated with several disorders and diseases, it's important to investigate the allelic and genotypic distribution among populations. The aim of this study is to determine the frequency of rs731236 (Taq1) and rs2228570 (Fok1) variants in healthy Emirati individuals and compare their genotype and allele distribution with other populations. In this study 282 (female, 187; male, 95) unrelated healthy UAE nationals were involved. Two hundreds and eight two DNA samples been collected to genotype rs731236 (Taq1) and rs2228570 (Fok1) VDR SNPs. Our results indicate that the distribution of the alleles and genotypes of rs731236 (Taq1) and rs2228570 (Fok1) vary considerably in different populations. In the Emirati population the distribution of rs731236 (Taq1) and rs2228570 (Fok1) were AA 38%, AG 42%, GG 20% and AA 27%, AG 42%, GG 31% respectively. The Emirati population genotype and allele distribution of rs731236 (Taq1) and rs2228570 (Fok1) had no difference with Caucasians from USA and France. However, there was significant difference with Asian populations.

DOI Link

10.1016/j.mgene.2015.09.001

ISSN

2214-5400

Publisher

Elsevier B.V.

Volume

6

First Page

49

Last Page

52

Disciplines

Life Sciences

Keywords

Genetic polymorphism, Rs731236 (Taq1) and rs2228570 (Fok1), UAE, VDR, Vitamin D

Scopus ID

84941952349

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.

Recommended Citation

Osman, Enas; Al Anouti, Fatme; El ghazali, Gehad; Haq, Afrozul; Mirgani, Rajaa; and Al Safar, Habiba, "Frequency of rs731236 (Taql), rs2228570 (Fok1) of Vitamin-D Receptor (VDR) gene in Emirati healthy population" (2015). All Works. 1722.
https://zuscholars.zu.ac.ae/works/1722

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Hybrid: This publication is openly available in a subscription-based journal/series