Document Type

Article

Source of Publication

International Journal of Endocrinology

Publication Date

1-1-2017

Abstract

Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.

ISSN

1687-8337

Publisher

Hindawi Limited

Volume

2017

First Page

2671692

Last Page

5

Disciplines

Medicine and Health Sciences

Keywords

glucose, high density lipoprotein, insulin, lipid, triacylglycerol, anthropometry, Article, body mass, cardiometabolic risk, child, disease association, disease course, echography, female, glucose blood level, hepatography, high risk patient, human, insulin blood level, insulin resistance, lipid blood level, major clinical study, male, metabolic syndrome X, nonalcoholic fatty liver, obesity, protein blood level, risk factor, school child, triacylglycerol blood level, waist circumference

Scopus ID

85036624907

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

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