Document Type
Article
Source of Publication
International Journal of Endocrinology
Publication Date
1-1-2017
Abstract
Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.
DOI Link
ISSN
Publisher
Hindawi Limited
Volume
2017
First Page
2671692
Last Page
5
Disciplines
Medicine and Health Sciences
Keywords
glucose, high density lipoprotein, insulin, lipid, triacylglycerol, anthropometry, Article, body mass, cardiometabolic risk, child, disease association, disease course, echography, female, glucose blood level, hepatography, high risk patient, human, insulin blood level, insulin resistance, lipid blood level, major clinical study, male, metabolic syndrome X, nonalcoholic fatty liver, obesity, protein blood level, risk factor, school child, triacylglycerol blood level, waist circumference
Scopus ID
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Papandreou, Dimitrios; Karavetian, Mirey; Karabouta, Zacharoula; and Andreou, Eleni, "Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome" (2017). All Works. 2529.
https://zuscholars.zu.ac.ae/works/2529
Indexed in Scopus
yes
Open Access
yes
Open Access Type
Gold: This publication is openly available in an open access journal/series