Source of Publication
International Journal of Endocrinology
Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.
Medicine and Health Sciences
glucose; high density lipoprotein; insulin; lipid; triacylglycerol; anthropometry; Article; body mass; cardiometabolic risk; child; disease association; disease course; echography; female; glucose blood level; hepatography; high risk patient; human; insulin blood level; insulin resistance; lipid blood level; major clinical study; male; metabolic syndrome X; nonalcoholic fatty liver; obesity; protein blood level; risk factor; school child; triacylglycerol blood level; waist circumference
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Papandreou, Dimitrios; Karavetian, Mirey; Karabouta, Zacharoula; and Andreou, Eleni, "Obese Children with Metabolic Syndrome Have 3 Times Higher Risk to Have Nonalcoholic Fatty Liver Disease Compared with Those without Metabolic Syndrome" (2017). All Works. 2529.
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Open Access Type
Gold: This publication is openly available in an open access journal/series