Document Type

Article

Source of Publication

International Journal of Endocrinology

Publication Date

1-1-2017

Abstract

Copyright © 2017 Dimitrios Papandreou et al. Background: The aim of this study was to investigate the relationship between metabolic syndrome (MS) and nonalcoholic fatty liver disease (NAFLD) in obese children. One hundred and twenty-five subjects aged 11-12 years old participated in the study. Methods: Anthropometric and biochemical indices were measured, including lipid and liver profile, blood glucose, serum insulin, and liver ultrasound. Results: Forty-four children (58.6%) were found to have MS. Insulin resistance was present in 78 (62.4%) children. Patients with MS were more likely to have NAFLD (P <; 0.001). Children with NAFLD had significantly higher body mass index, waist circumference, triglycerides, fasting insulin, and lower high-density lipoprotein compared to patients with normal livers (P < 0.001). Insulin resistance was significantly higher in children with NAFLD (P <; 0.001). Obese children presenting with MS were 3.01 (2.87-3.57, P < 0.002) times more likely to develop NAFLD compared to those without metabolic syndrome after adjustment of cofounders. Conclusions: Obese children with MS have a higher risk of developing NAFLD. Weight management and early prevention should be the first line of treatment to prevent any possible health issues later on.

ISSN

1687-8337

Publisher

Hindawi Limited

Volume

2017

First Page

2671692

Last Page

5

Disciplines

Medicine and Health Sciences

Keywords

glucose; high density lipoprotein; insulin; lipid; triacylglycerol; anthropometry; Article; body mass; cardiometabolic risk; child; disease association; disease course; echography; female; glucose blood level; hepatography; high risk patient; human; insulin blood level; insulin resistance; lipid blood level; major clinical study; male; metabolic syndrome X; nonalcoholic fatty liver; obesity; protein blood level; risk factor; school child; triacylglycerol blood level; waist circumference

Scopus ID

85036624907

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

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