A review on myricetin as a potential therapeutic candidate for cancer prevention

Document Type

Article

Source of Publication

3 Biotech

Publication Date

5-1-2020

Abstract

© 2020, King Abdulaziz City for Science and Technology. Myricetin, one of the most extensively studied polyphenols, is present abundantly in various fruits and vegetables and exhibits diverse pharmacological properties. The multifaceted biological action of myricetin against tumor heterogeneity makes it an impressive anticancer agent whose efficacy has been confirmed by an overwhelming number of studies. Myricetin shows its therapeutic potential by targeting and modulating the expression of various molecular target which are involved in inflammation, cell proliferation, apoptosis, angiogenesis, invasion, and metastasis. Myricetin deters tumor progression by inducing apoptosis via both intrinsic and extrinsic pathway, activating/inactivating several signaling pathways, and reactivating various tumor suppressor genes. This comprehensive review represents the effect of myricetin on various hallmarks of cancer with insight into the molecular mechanism employed by myricetin to mitigate cell proliferation, angiogenesis, metastasis, and induce apoptosis. In addition, enhanced bioavailability of myricetin through conjugation and its increased efficacy as an anticancer agent when used in combination are also highlighted.

ISSN

2190-5738

Publisher

Springer

Volume

10

Issue

5

First Page

211

Disciplines

Life Sciences

Keywords

Apoptotic proteins, Caspases, Immunomodulation, Myricetin, NLRP3 inflammasome, ROS, TNF

Scopus ID

85083865021

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Green: A manuscript of this publication is openly available in a repository

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