Skeletal muscle and the maintenance of vitamin d status

Author First name, Last name, Institution

Mark S. Rybchyn
Myriam Abboud
David A. Puglisi
Clare Gordon-Thomson
Tara C. Brennan-Speranza
Rebecca S. Mason
David R. Fraser

ORCID Identifiers

0000-0002-4336-6227

0000-0001-8025-7823

0000-0003-1534-9697

0000-0003-2560-0750

Document Type

Article

Source of Publication

Nutrients

Publication Date

11-1-2020

Abstract

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. Vitamin D, unlike the micronutrients, vitamins A, E, and K, is largely obtained not from food, but by the action of solar ultraviolet (UV) light on its precursor, 7-dehydrocholesterol, in skin. With the decline in UV light intensity in winter, most skin production of vitamin D occurs in summer. Since no defined storage organ or tissue has been found for vitamin D, it has been assumed that an adequate vitamin D status in winter can only be maintained by oral supplementation. Skeletal muscle cells have now been shown to incorporate the vitamin D-binding protein (DBP) from blood into the cell cytoplasm where it binds to cytoplasmic actin. This intracellular DBP provides an array of specific binding sites for 25-hydroxyvitamin D (25(OH)D), which diffuses into the cell from the extracellular fluid. When intracellular DBP undergoes proteolytic breakdown, the bound 25(OH)D is then released and diffuses back into the blood. This uptake and release of 25(OH)D by muscle accounts for the very long half-life of this metabolite in the circulation. Since 25(OH)D concentration in the blood declines in winter, its cycling in and out of muscle cells appears to be upregulated. Parathyroid hormone is the most likely factor enhancing the repeated cycling of 25(OH)D between skeletal muscle and blood. This mechanism appears to have evolved to maintain an adequate vitamin D status in winter.

DOI Link

10.3390/nu12113270

ISSN

2072-6643

Publisher

MDPI AG

Volume

12

Issue

11

First Page

1

Last Page

11

Disciplines

Life Sciences

Keywords

Muscle, Parathyroid hormone, Vitamin D, Vitamin D-binding proteinff

Scopus ID

85094867922

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Recommended Citation

Rybchyn, Mark S.; Abboud, Myriam; Puglisi, David A.; Gordon-Thomson, Clare; Brennan-Speranza, Tara C.; Mason, Rebecca S.; and Fraser, David R., "Skeletal muscle and the maintenance of vitamin d status" (2020). All Works. 3102.
https://zuscholars.zu.ac.ae/works/3102

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series