Sunlight exposure is just one of the factors which influence Vitamin D status

Author First name, Last name, Institution

M. Abboud, Zayed UniversityFollow
M. S. Rybchyn, Sydney Medical School
R. Rizk, Maastricht University
D. R. Fraser, The University of Sydney
R. S. Mason, Sydney Medical School

ORCID Identifiers

0000-0002-8850-6502

0000-0003-1534-9697

Document Type

Article

Source of Publication

Photochemical and Photobiological Sciences

Publication Date

1-1-2017

Abstract

© The Royal Society of Chemistry and Owner Societies. Studies on the determinants of vitamin D status have tended to concentrate on input-exposure to ultraviolet B radiation and the limited sources in food. Yet, vitamin D status, determined by circulating concentrations of 25-hydroxyvitamin D (25(OH)D), can vary quite markedly in groups of people with apparently similar inputs of vitamin D. There are small effects of polymorphisms in the genes for key proteins involved in vitamin D production and metabolism, including 7-dehydrocholesterol reductase, which converts 7-dehydrocholesterol, the precursor of vitamin D, to cholesterol, CYP2R1, the main 25-hydroxylase of vitamin D, GC, coding for the vitamin D binding protein which transports 25(OH)D and other metabolites in blood and CYP24A1, which 24-hydroxylates both 25(OH)D and the hormone, 1,25-dihydroxyvitamin D. 25(OH)D has a highly variable half-life in blood. There is evidence that the half-life of 25(OH)D is affected by calcium intake and some therapeutic agents. Fat tissue seems to serve as a sink for the parent vitamin D, which is released mainly when there are reductions in adiposity. Some evidence is presented to support the proposal that skeletal muscle provides a substantial site of sequestration of 25(OH)D, protecting this metabolite from degradation by the liver, which may help to explain why exercise, not just outdoors, is usually associated with better vitamin D status.

DOI Link

10.1039/c6pp00329j

ISSN

1474-905X

Publisher

Royal Society of Chemistry

Volume

16

Issue

3

First Page

302

Last Page

313

Disciplines

Medicine and Health Sciences

Keywords

vitamin D, blood, human, metabolism, risk factor, sunlight, Humans, Risk Factors, Sunlight, Vitamin D

Scopus ID

85015711938

Recommended Citation

Abboud, M.; Rybchyn, M. S.; Rizk, R.; Fraser, D. R.; and Mason, R. S., "Sunlight exposure is just one of the factors which influence Vitamin D status" (2017). All Works. 3254.
https://zuscholars.zu.ac.ae/works/3254

Indexed in Scopus

yes

Open Access

no