Source of Publication
Journal of Chromatography & Separation Techniques
About 90% of diabetic patients around the world have type 2 diabetes mellitus according to the World Health Organization.A significant proportion of the health care system resources worldwide are devoted to cover diagnosis, treatment and management of type 2 diabetes . Moreover, it is associated with morbidity like blindness, renal failure and mortality. Type 2 diabetesis a progressive chronic disease which is marked by the inability of tissues like liver and skeletal muscles to respond to the hormone insulin which is secreted by the pancreas. Several risk factors like genetics, environmental factors and obesity contribute to the development of type 2 diabetes. Studies on genes which predispose to type 2 diabeteshave been conducted by various researchers among different ethnic populations. Genome wide association studies have led to the identification of many single nucleotide polymorphisms in certain genes and linked them to type 2 diabetes [2,3]. Recently, genes involved in vitamin D metabolism have gained interest because of the association between vitamin D deficiency and type 2 diabetes. High vitamin D levels were significantly associated with reduced risk for type 2 diabetes among Australian adult men and . Vitamin D deficiency results in reduced insulin secretion in humans and rats, and its supplementation improves glucose tolerance . One major study has suggested that vitamin D supplementation could lead to a significant reduction in mortality . In addition, vitamin D is required for absorption of dietary calcium. Calcium is essential for insulin-mediated processes in insulin responsive tissues. Calcium repletion normalizes glucose tolerance and secretion of insulin in vitamin D-depleted rats and hypocalcemia in nondiabetics reduces insulin secretion .
OMICS Publishing Group
Medicine and Health Sciences
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This work is licensed under a Creative Commons Attribution 4.0 License.
Al Anouti, Fatme, "Vitamin D Receptor Interactions and Genetic Variants in the Context of Type 2 Diabetes Mellitus" (2013). All Works. 3921.
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Hybrid: This publication is openly available in a subscription-based journal/series