Document Type

Article

Source of Publication

Macedonian Journal of Medical Sciences

Publication Date

9-15-2016

Abstract

© 2016 Zujaja-Tul-Noor Hamid Mehmood, Dimitrios Papandreou. Vitamin D related research continues to expand and theorise regarding its involvement in obesity, as both hypovitaminosis D and obesity strike in pandemic proportions. Vitamin D plays an important role in immune system through Vitamin D Receptors (VDR), which are transcription factors located abundantly in the body. Due to this characteristic, it is potentially linked to obesity, which is a state of inflammation involving the release of cytokines from adipose tissue, and exerting stress on other organs in a state of positive energy balance. Research trials in the past couple of years and systematic reviews from SCOPUS and MEDLINE will be discussed. The role of Vitamin D throughout the lifespan (from fetal imprinting until older age), and in various other obesity mediated chronic conditions shall be highlighted. Various mechanisms attributed to the inverse relationship of Vitamin D and obesity are discussed with research gaps identified, particularly the role of adipokines, epigenetics, calcium and type of adipose tissue.

ISSN

1857-9655

Publisher

Institute of Immunobiology and Human Genetics

Volume

4

Issue

3

First Page

526

Last Page

532

Disciplines

Life Sciences

Keywords

1, 25(OH)2D3, Adipocyte, Inflammation, Obesity

Scopus ID

84988985775

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

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Life Sciences Commons

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