Document Type

Article

Source of Publication

Biomedicines

Publication Date

7-1-2022

Abstract

Though several previous studies reported the in vitro and in vivo antioxidant effect of kinetin (Kn), details on its action in cisplatin‐induced toxicity are still scarce. In this study we eval-uated, for the first time, the effects of kinetin in cisplatin (cp)‐ induced liver and lymphocyte toxicity in rats. Wistar male albino rats were divided into nine groups: (i) the control (C), (ii) groups 2,3 and 4, which received 0.25, 0.5 and 1 mg/kg kinetin for 10 days; (iii) the cisplatin (cp) group, which received a single intraperitoneal injection of CP (7.0 mg/kg); and (iv) groups 6, 7, 8 and 9, which received, for 10 days, 0.25, 0.5 and 1 mg/kg kinetin or 200 mg/kg vitamin C, respectively, and Cp on the fourth day. CP‐injected rats showed a significant impairment in biochemical, oxidative stress and inflammatory parameters in hepatic tissue and lymphocytes. PCR showed a profound increase in caspase‐3, and a significant decline in AKT gene expression. Intriguingly, Kn treatment restored the biochemical, redox status and inflammatory parameters. Hepatic AKT and caspase‐3 expression as well as CD95 levels in lymphocytes were also restored. In conclusion, Kn mitigated oxidative imbalance, inflammation and apoptosis in CP‐induced liver and lymphocyte toxicity; therefore, it can be considered as a promising therapy.

ISSN

2227-9059

Publisher

MDPI AG

Volume

10

Issue

7

Disciplines

Life Sciences

Keywords

AKT, Caspase‐3, CD95, cisplatin, hepatotoxicity, lymphotoxicity, oxidative stress

Scopus ID

85134004719

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

Download

Included in

Life Sciences Commons

Share

COinS