The Association of Peptide Hormones with Glycemia, Dyslipidemia, and Obesity in Lebanese Individuals
Document Type
Article
Source of Publication
Metabolites
Publication Date
11-1-2022
Abstract
Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of these peptide-hormones with obesity-markers, insulin-resistance, and dyslipidemia (total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), triglyceride (TG)). Sixteen-obese (OB) adults and 21 normal-weight (NW) age-and gender-matched counterparts were recruited. OB-participants showed significantly higher levels of leptin, insulin, Homeostatic-Model Assessment of Insulin Resistance (HOMA-IR), and TG. NW participants had significantly higher levels of ghrelin. GLP-1 was positively correlated with insulin, HOMA-IR, and obesity-markers except percent body fat. Leptin was positively correlated with all markers (except glucose and dyslipidemia). PYY was positively correlated with BMI, insulin and HOMA-IR. Ghrelin was inversely correlated with all of the markers except glucose, TC, and LDL-C. In the regression analysis model, leptin was positively associated with obesity markers and insulin resistance. Our results indicate a significant difference in peptide hormones among OB and NW Lebanese individuals. Since there is controversial evidence regarding body-weight and peptide-hormones in the literature, this study highlights a step forward towards finding ethnic based strategies to treat obesity and its consequences.
DOI Link
ISSN
Publisher
MDPI AG
Volume
12
Issue
11
Disciplines
Medicine and Health Sciences
Keywords
cholecystokinin, dyslipidemia, ghrelin, glucagon-like peptide-1, insulin resistance, leptin, obesity, pancreatic peptide YY
Scopus ID
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Abou-Samra, Murielle; Venema, Koen; Ayoub Moubareck, Carole; and Karavetian, Mirey, "The Association of Peptide Hormones with Glycemia, Dyslipidemia, and Obesity in Lebanese Individuals" (2022). All Works. 5479.
https://zuscholars.zu.ac.ae/works/5479
Indexed in Scopus
yes
Open Access
yes
Open Access Type
Gold: This publication is openly available in an open access journal/series