Document Type
Article
Source of Publication
Informatics in Medicine Unlocked
Publication Date
1-1-2024
Abstract
Sepsis continues to be recognized as a significant global health challenge across all ages and is characterized by a complex pathophysiology. In this scoping review, PRISMA-ScR guidelines were adhered to, and a transcriptomic methodology was adopted, with the protocol registered on the Open Science Framework. We hypothesized that gene expression analysis could provide a foundation for establishing a clinical research framework for sepsis. A comprehensive search of the PubMed database was conducted with a particular focus on original research and systematic reviews of transcriptomic sepsis studies published between 2012 and 2022. Both coding and non-coding gene expression studies have been included in this review. An effort was made to enhance the understanding of sepsis at the mRNA gene expression level by applying a systems biology approach through transcriptomic analysis. Seven crucial components related to sepsis research were addressed in this study: endotyping (n = 64), biomarker (n = 409), definition (n = 0), diagnosis (n = 1098), progression (n = 124), severity (n = 451), and benchmark (n = 62). These components were classified into two groups, with one focusing on Biomarkers and Endotypes and the other oriented towards clinical aspects. Our review of the selected studies revealed a compelling association between gene transcripts and clinical sepsis, reinforcing the proposed research framework. Nevertheless, challenges have arisen from the lack of consensus in the sepsis terminology employed in research studies and the absence of a comprehensive definition of sepsis. There is a gap in the alignment between the notion of sepsis as a clinical phenomenon and that of laboratory indicators. It is potentially responsible for the variable number of patients within each category. Ideally, future studies should incorporate a transcriptomic perspective. The integration of transcriptomic data with clinical endpoints holds significant potential for advancing sepsis research, facilitating a consensus-driven approach, and enabling the precision management of sepsis.
DOI Link
ISSN
Publisher
Elsevier BV
Volume
44
First Page
101419
Last Page
101419
Disciplines
Medicine and Health Sciences
Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-No Derivative Works 4.0 International License.
Recommended Citation
Rashid, Asrar; Al-Obeidat, Feras; Kanthimathinathan, Hari Krishnan; Benakatti, Govind; Hafez, Wael; Ramaiah, Raghu; Brierley, Joe; Hanisch, Benjamin; Khilnani, Praveen; Koutentis, Christos; Brusletto, Berit S.; Toufiq, Mohammed; Hussain, Zain; Vyas, Harish; Malik, Zainab A; Schumacher, Maike; Malik, Rayaz A; Deshpande, Shriprasad; Quraishi, Nasir; Kadwa, Raziya; Sarpal, Amrita; Shaikh, M. Guftar; Sharief, Javed; Zaki, Syed Ahmed; Phatak, Rajesh; Deep, Akash; Al-Dubai, Ahmed; and Hussain, Amir, "Advancing sepsis clinical research: harnessing transcriptomics for an omics-based strategy - a comprehensive scoping review" (2024). All Works. 6244.
https://zuscholars.zu.ac.ae/works/6244
Indexed in Scopus
no
Open Access
yes
Open Access Type
Hybrid: This publication is openly available in a subscription-based journal/series