Document Type
Article
Source of Publication
Molecules
Publication Date
3-1-2024
Abstract
Epigallocatechin gallate (EGCG) is a catechin, which is a type of flavonoid found in high concentrations in green tea. EGCG has been studied extensively for its potential health benefits, particularly in cancer. EGCG has been found to exhibit anti-proliferative, anti-angiogenic, and pro-apoptotic effects in numerous cancer cell lines and animal models. EGCG has demonstrated the ability to interrupt various signaling pathways associated with cellular proliferation and division in different cancer types. EGCG anticancer activity is mediated by interfering with various cancer hallmarks. This article summarize and highlight the effects of EGCG on cancer hallmarks and focused on the impacts of EGCG on these cancer-related hallmarks. The studies discussed in this review enrich the understanding of EGCG’s potential as a therapeutic tool against cancer, offering a substantial foundation for scientists and medical experts to advance scientific and clinical investigations regarding EGCG’s possibility as a potential anticancer treatment.
DOI Link
ISSN
Publisher
MDPI AG
Volume
29
Issue
6
Disciplines
Medicine and Health Sciences
Keywords
angiogenesis, anticancer, cancer hallmarks, epigallocatechin gallate (EGCG), immune evasion, metastasis
Scopus ID
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Recommended Citation
Talib, Wamidh H.; Awajan, Dima; Alqudah, Abdelrahim; Alsawwaf, Razan; Althunibat, Raha; Abu AlRoos, Mahmoud; Al Safadi, Ala’a; Abu Asab, Sharif; Hadi, Rawan W.; and Al Kury, Lina T., "Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets" (2024). All Works. 6538.
https://zuscholars.zu.ac.ae/works/6538
Indexed in Scopus
yes
Open Access
yes
Open Access Type
Gold: This publication is openly available in an open access journal/series