Document Type

Article

Source of Publication

Photochemical and Photobiological Sciences

Publication Date

1-1-2024

Abstract

Abstract: Common therapeutics in relation to melanoma and non-melanoma cancers include the use of kinase inhibitors. The long-term benefits of kinases, however, are limited by development of drug resistance. An alternative approach for treatment would be to focus on transcription factors. Cyclic AMP-regulatory element-binding protein (CREB) is a transcription factor that is commonly overactivated or overexpressed in many different cancers including skin cancer. Ultraviolet radiation (UVR), one of the main causes of skin cancer, can activate CREB in both melanocytes and keratinocytes. In addition, CREB has been found to be activated in skin cancers. Considering the prominent role that CREB plays in skin cancers, the studies reviewed herein raise the possibility of CREB as a potential prognostic and diagnostic marker of skin cancer and a novel target for therapeutic intervention. Graphical Abstract: (Figure presented.).

ISSN

1474-905X

Publisher

Springer Science and Business Media LLC

Disciplines

Medicine and Health Sciences

Keywords

cAMP-regulatory element-binding protein (CREB), Melanoma skin cancer, Non-melanoma skin cancer, Ultraviolet radiation

Scopus ID

85192956655

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Hybrid: This publication is openly available in a subscription-based journal/series

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