Document Type

Article

Source of Publication

Journal of Diabetes Research

Publication Date

1-1-2018

Abstract

© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

ISSN

2314-6745

Publisher

Hindawi Limited

Volume

2018

First Page

2974304

Last Page

15

Disciplines

Life Sciences

Keywords

animal, calcium signaling, cardiac muscle, cardiac muscle cell, disease model, glucose blood level, heart ventricle, metabolism, non insulin dependent diabetes mellitus, physiology, rat, Animals, Blood Glucose, Calcium Signaling, Diabetes Mellitus, Type 2, Disease Models, Animal, Heart Ventricles, Myocardium, Myocytes, Cardiac, Rats

Scopus ID

85054740012

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

Download

Included in

Life Sciences Commons

Share

COinS