Document Type

Article

Source of Publication

Journal of Diabetes Research

Publication Date

1-1-2018

Abstract

© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.

ISSN

2314-6745

Publisher

Hindawi Limited

Volume

2018

First Page

2974304

Last Page

15

Disciplines

Life Sciences

Keywords

animal; calcium signaling; cardiac muscle; cardiac muscle cell; disease model; glucose blood level; heart ventricle; metabolism; non insulin dependent diabetes mellitus; physiology; rat; Animals; Blood Glucose; Calcium Signaling; Diabetes Mellitus, Type 2; Disease Models, Animal; Heart Ventricles; Myocardium; Myocytes, Cardiac; Rats

Scopus ID

85054740012

Creative Commons License

Creative Commons Attribution 4.0 License
This work is licensed under a Creative Commons Attribution 4.0 License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

Included in

Life Sciences Commons

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