Source of Publication
Journal of Diabetes Research
© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.
animal, calcium signaling, cardiac muscle, cardiac muscle cell, disease model, glucose blood level, heart ventricle, metabolism, non insulin dependent diabetes mellitus, physiology, rat, Animals, Blood Glucose, Calcium Signaling, Diabetes Mellitus, Type 2, Disease Models, Animal, Heart Ventricles, Myocardium, Myocytes, Cardiac, Rats
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
Al Kury, L.; Smail, M.; Qureshi, M. A.; Sydorenko, V.; Shmygol, A.; Oz, M.; Singh, J.; and Howarth, F. C., "Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat" (2018). All Works. 811.
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Open Access Type
Gold: This publication is openly available in an open access journal/series