Source of Publication
Journal of Diabetes Research
© 2018 L. Al Kury et al. The association between diabetes mellitus (DM) and high mortality linked to cardiovascular disease (CVD) is a major concern worldwide. Clinical and preclinical studies have demonstrated a variety of diastolic and systolic dysfunctions in patients with type 2 diabetes mellitus (T2DM) with the severity of abnormalities depending on the patients' age and duration of diabetes. The cellular basis of hemodynamic dysfunction in a type 2 diabetic heart is still not well understood. The aim of this review is to evaluate our current understanding of contractile dysfunction and disturbances of Ca2+ transport in the Goto-Kakizaki (GK) diabetic rat heart. The GK rat is a widely used nonobese, nonhypertensive genetic model of T2DM which is characterized by insulin resistance, elevated blood glucose, alterations in blood lipid profile, and cardiac dysfunction.
animal; calcium signaling; cardiac muscle; cardiac muscle cell; disease model; glucose blood level; heart ventricle; metabolism; non insulin dependent diabetes mellitus; physiology; rat; Animals; Blood Glucose; Calcium Signaling; Diabetes Mellitus, Type 2; Disease Models, Animal; Heart Ventricles; Myocardium; Myocytes, Cardiac; Rats
Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.
Al Kury, L.; Smail, M.; Qureshi, M. A.; Sydorenko, V.; Shmygol, A.; Oz, M.; Singh, J.; and Howarth, F. C., "Calcium signaling in the ventricular myocardium of the Goto-Kakizaki type 2 diabetic rat" (2018). All Works. 811.
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Open Access Type
Gold: This publication is openly available in an open access journal/series