Document Type

Article

Source of Publication

Frontiers in Pharmacology

Publication Date

7-18-2017

Abstract

© 2017 Oz, El Nebrisi, Yang, Howarth and Al Kury. Menthol belongs to monoterpene class of a structurally diverse group of phytochemicals found in plant-derived essential oils. Menthol is widely used in pharmaceuticals, confectionary, oral hygiene products, pesticides, cosmetics, and as a flavoring agent. In addition, menthol is known to have antioxidant, anti-inflammatory, and analgesic effects. Recently, there has been renewed awareness in comprehending the biological and pharmacological effects of menthol. TRP channels have been demonstrated to mediate the cooling actions of menthol. There has been new evidence demonstrating that menthol can significantly influence the functional characteristics of a number of different kinds of ligand and voltage-gated ion channels, indicating that at least some of the biological and pharmacological effects of menthol can be mediated by alterations in cellular excitability. In this article, we examine the results of earlier studies on the actions of menthol with voltage and ligand-gated ion channels.

ISSN

1663-9812

Publisher

Frontiers Media S.A.

Volume

8

Issue

JUL

First Page

472

Last Page

472

Disciplines

Medicine and Health Sciences

Keywords

Ligand-gated ion channels, Menthol, Monoterpenes, TRP channels, Voltage-gated ion channels

Scopus ID

85025472344

Creative Commons License

Creative Commons Attribution 4.0 International License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Indexed in Scopus

yes

Open Access

yes

Open Access Type

Gold: This publication is openly available in an open access journal/series

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