Thymulin related peptide attenuates inflammation in the brain induced by intracerebroventricular endotoxin injection

Document Type

Article

Source of Publication

Neuropharmacology

Publication Date

2-1-2011

Abstract

Based on significant amount of evidence, it is now generally believed, that one underlying cause for neurodegenerative diseases, could be dysregulation in inflammatory processes. The actual mechanisms involved are not yet well understood. Several studies have demonstrated the potent analgesic and anti-inflammatory actions of thymulin related peptide (PAT), in different animal pain models. In this study, we investigated the efficacy of PAT in a recently developed model of neuroinflammation, in conscious rats, caused by intracerbroventricular (ICV) injection of endotoxin (ET). Our results indicate that ICV injection of PAT alone did not elicit significant alteration of nociceptive thresholds, while ET injections produced significant thermal hyperalgesia and cold allodynia. Pretreatment with PAT resulted in significant alleviation of ET-induced hyperalgesia and increased body temperature. In other sets of experiments, ICV injection of ET resulted in a significant elevation in the concentration of pro-inflammatory mediators measured in different areas of the brain; this elevation was significantly following pretreatment with PAT. Taken together these results provide evidence in support of our hypothesis that as a potent anti-inflammatory and analgesic peptide, PAT might have potential therapeutic use for the treatment of neurodegenerative conditions induced by silent or overt inflammation. © 2010 Elsevier Ltd. All rights reserved.

ISSN

0028-3908

Publisher

Elsevier

Volume

60

Issue

2-3

First Page

496

Last Page

504

Disciplines

Life Sciences

Keywords

Analgesia, Cytokines, Hyperalgesia, Neuroinflammation, Neurotrophins, Thymulin

Scopus ID

78650834290

Indexed in Scopus

yes

Open Access

no

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